Animal Models of Ophthalmic Diseases by Chi-Chao Chan

By Chi-Chao Chan

This booklet describes experimental animal versions that mimic universal human ocular illnesses: herpetic keratitis, cataract, glaucoma, age-related macular degeneration, diabetic retinopathy, uveitis, retinitis pigmentosa, Graves’ illness, and intraocular tumors. In conjunction, those versions replicate the range and application of instruments used to check human ailment. global professional clinicians speak about each one version in line with their scientific event and the textual content is supported by means of quite a few photographs and diagrams. In describing the main pertinent animal types of ophthalmic ailments, this ebook can be of curiosity to ophthalmologists, imaginative and prescient researchers, fellows, citizens and scientific students.

Show description

Read or Download Animal Models of Ophthalmic Diseases PDF

Similar ophthalmology books

Cicatrising Conjunctivitis (Developments in Ophthalmology)

Cicatrizing conjunctivitis is likely one of the such a lot demanding explanations of ocular floor illness this day, and with no applicable intervention, corneal blindness or lack of sight from supervening an infection is usual. simply because lots of those illnesses are infrequent, there's usually constrained administration adventure to be had and the assets for examine into remedy and pathogenesis could be scarce.

Tumors of the Eye and Ocular Adnexa (Atlas of Clinical Oncology)

American melanoma Society Atlas of medical Oncology ACS Tumors of the attention and Ocular Adnexa Tumors of the attention and Ocular Adnexa is an authoritative and complete color atlas that would serve the source wishes of the coed and the practitioner fascinated with the therapy of tumors of the attention, orbit, and periorbital constructions - lids, lacrinal glands, and adnaxae.

Postgraduate Ophthalmology

This well-illustrated quantity set covers the sector of ophthalmology, from the basics to the newest advances. each one part is devoted to a selected quarter of the attention and covers uncomplicated suggestions, investigative modules and remedy equipment. With assistance from 2500 photographs and illustrations, this booklet covers subject matters comparable to glaucoma, ocular oncology, nystagmus, refractive surgical procedure, strabismus and lasers in ophthalmology.


Gonioscopy is a vital differential diagnostic software that allows evaluate of the anterior chamber attitude and proper category of glaucoma as a foundation for particular remedy. This booklet sincerely explains the way to practice gonioscopy to top impression. The anatomy of the chamber attitude is systematically defined, and the impression of age, developmental problems, and different pathologies at the chamber perspective is defined.

Additional resources for Animal Models of Ophthalmic Diseases

Example text

Many of the rabbit studies investigate the preventive effect of contact lenses containing UV-blocking materials. These findings show that contact lenses are beneficial in protecting ocular tissues of the rabbit against harmful effects of UV light, including photokeratitis and anterior subcapsular cataract (Giblin et al. 2012). 3 Steroid-Induced Cataracts The use of steroid therapy in recent years has contributed to an increase in the incidence of cataracts (Gupta and Wagner 2009; Watanabe et al.

Pathologies Oculaires Liees a l’Age. Am J Epidemiol 151(5):497–504 DeRosa AM, Xia CH, Gong X, White TW (2007) The cataract-inducing S50P mutation in Cx50 dominantly alters the channel gating of wild-type lens connexins. J Cell Sci 120(Pt 23):4107–4116. 012237 DeRosa AM, Mese G, Li L, Sellitto C, Brink PR, Gong X, White TW (2009) The cataract causing Cx50-S50P mutant inhibits Cx43 and intercellular communication in the lens epithelium. Exp Cell Res 315(6):1063– 1075. 017 Devi RR, Yao W, Vijayalakshmi P, Sergeev YV, Sundaresan P, Hejtmancik JF (2008) Crystallin gene mutations in Indian families with inherited pediatric cataract.

Homozygous Cx46-null mice developed nuclear cataracts that formed due to aggregation 2 Animal Models of Cataracts of lens protein, facilitated by the degradation of crystallins (Gong et al. 1997). This mouse model showed normal early lens development, but with small opacities forming 2–3 weeks after birth that continued into full nuclear cataracts by 2 months, with 100 % penetrance of cataracts reported, indicating Cx46 is required for proper lens function (Gong et al. 1997). Interestingly, the severity of the cataracts on the Cx46-null model varied depending on the breeding background of the mouse, with milder cataracts observed in C57B16 mice when compared with mice bred from the 129 strain (Gong et al.

Download PDF sample

Rated 4.48 of 5 – based on 38 votes