An Experimental Study of Pituitary Tumours: Genesis, by Hong Giok Kwa

By Hong Giok Kwa

"Let the states of equilibrium and concord exist in perfection and a contented order will succeed via heaven and earth and all issues might be nourrished and flourish. " (MENCIUS, in "The Doctrine of the Mean." ) of their typical setting a few of the vegetation and animals that experience inhabited a area for a long time have stumbled on a common stability. The inhabitants of vegetation and animals of the sort of sector looks to manage itself car matically; the variety of each one species is stored inside of particularly strict limits by way of a average stability of forces. The advent of a brand new aspect in such an equilibrated state of affairs can result in a "disaster" while the stability of forces that acted as an ideal self-steering equipment up until the advent of that new aspect, fails to maintain the variety of that aspect lower than keep an eye on. a widely known instance for this sort of (man's) "interference with nature's stability of forces" is the importation of rabbits in Australia. simply because Australia's fauna didn't comprise any of the rabbit's "natural enemies" a "rabbit inhabitants explosion" this unsatisfied determination. An equilibrated scenario can develop into disturbed otherwise. An instance of one other form of (man's) "interference with nature's stability of forces" is the creation of contemporary know-how and drugs in up until lately "backward" international locations. the consequent elevate in on hand foodstuff and the higher hygienic criteria got rid of the older tests on inhabitants bring up similar to famine and peri-natal dying.

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2. O. O. 7. 8. O. 1. 10. 3. 5. 18. 15. O. O. 1 Pituitary weight data of males, orchidectomized males, females and spayed females in the different strains of mice have been pooled. • n. = number of pituitaries weighing 3 mg or less, considered "normal". e. = number of pituitaries weighing between 3 mg and 12 mg, considered "enlarged" . t. = number of pituitaries weighing 12 mg or more, considered "tumourously enlarged". times of occurrence of pituitary tumours as well as the times needed by the tumours to attain comparable sizes are of approximately the same magnitude in the two treatment groups.

Microscopic examination of the trachea and its muscles, including the whole thyroid region, showed that in five series of radioactive iodine administrations the radiation delivered to the thyroid gland had not been sufficient to destroy it totally. The majority of the rats that were "radiothyroidectomized" only and all the rats that received thyroxin in their drinking water in addition, belonged to these five series; all the rats, which received oestrone treatment in addition were of the two last series and showed only scar tissue in the thyroid region.

2 "Duration of treatment" for the untreated rats = actual age 75 days. 3 Administration of radioactive iodine in this group of rats resulted in an incomplete destruction of the thyroid gland in the majority of animals (see text). 4 n. = number of pituitaries weighing 12 mg or less, considered "normal". e. = number of pituitaries weighing between 12 mg and 30 mg, considered "enlarged" . t. = number of pituitaries weighing 30 mg or more, considered "tumourously enlarged" . 5 Mean tumour weight: 117 mg; range: 77 mg-195 mg.

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